Fucked by the fickle finger of fate vulgar slang
If someone is fucked by the fickle finger of fate, they have gone through an unlucky situation.
I closed my newly-opened restaurant due to the pandemic. I was fucked by the fickle finger of fate.
To encounter bad luck, or being picked doing something undesirable
It is impossible for a person to change his or her innate or fundamental nature.
He said he would quit alcohol, but he still can't desist from drinking. Once an alcoholic, always an alcoholic.